6b.9 - Summary

In this lesson, among other things, we learned:

  • Distinguish between superiority, non-inferiority and equivalence trials in terms of
    • objectives
    • control group
    • hypotheses tested and
    • formation of confidence intervals.
  • Recognize the characteristics of a clinical trial with high external validity
  • Define which data are included in an intention-to-treat analysis
  • Recognize the major considerations for designing an equivalence or non-inferiority trial.
  • Perform sample size calculations for some equivalence and non-inferiority trials, using SAS programs.