Here we consider the joint estimation of a multivariate set of population means. That is, we have observed a set of p Xvariables and may wish to estimate the population mean for each variable. In some instances, we may also want to estimate one or more linear combinations of population means. Our basic tool for estimating the unknown value of a population parameter is a confidence interval, an interval of values that is likely to include the unknown value of the parameter.
 General Format for a Confidence Interval

The general format of a confidence interval estimate of a population mean is:

\(\text{Sample mean} \pm \text{Multiplier × Standard error of mean}\)

For variable \(X_{j}\), a confidence interval estimate of its population mean \(\mu_{j}\) is

\(\bar{x}_j \pm \text{Multiplier}\dfrac{s_j}{\sqrt{n}}\)
In this formula, \(\bar{x}_{j}\) is the sample mean, \(s_{j}\) is the sample standard deviation and n is the sample size. The multiplier value is a function of the confidence level, the sample size, and the strategy used for dealing with the multiple inference issue.
Strategies for Determining the Multiplier Section
The following list covers some common strategies:
 One at a Time Confidence Intervals: This strategy essentially considers each mean separately and uses the desired confidence level (usually 95%) for each single interval.
 Bonferroni Method: With this method we set a family wide error rate and then divide this family error rate by the number of intervals to be computed to determine the error rate (and hence confidence level) for each individual interval.
 Simultaneous Confidence Region: This strategy uses properties of the multivariate normal distribution to define joint confidence intervals. The multiplier for this method is conservative because the family error rate applies to the family of all possible linear combinations of population means.
One at a Time Intervals Section
For a \(1  α\) confidence interval, the “one at a time” multiplier is the tvalue such that the probability is \(1  α\) between –t and +t under a tdistribution with n  1 degrees of freedom. Said another way, the value of t is such that the probability greater than +t is \(α/2\).
Notationally, the one at a time multiplier is:
\(\text{Multiplier} = t_{n1}(\alpha/2)\)
With this notation, a confidence interval for \(\mu_{j}\) is computed as:
\(\bar{x}_j \pm t_{n1}(\alpha/2)\frac{s_j}{\sqrt{n}}\)
Example 51: One at a Time Intervals
Suppose that the sample size is n = 25 and we want a 95% confidence interval for the population mean. Thus \(α = 0.05\). Our textbook would write the multiplier as \(t_{24}(.025)\). In Excel, the command =TINV(.05,24) will give the multiplier (value = 2.064). In SAS, a command such as t1=tinv(.975,24) will make the variable t1 that contains the desired multiplier.
Bonferroni Method Multiplier Section
When we determine confidence intervals for the population means of several variables, we are creating a family of confidence intervals. The familywide error rate is the probability that at least one of the confidence intervals in the family will not capture the population mean. The familywide confidence level = 1 – familywide error rate.
Suppose that we have a family of p confidence intervals and the error rates for the individual intervals are \(\alpha _ { 1 } , \alpha _ { 2 } , \dots , \alpha _ { p }\). The Bonferroni Inequality states that the family wideerror rate is less than or equal to the sum of \(\alpha _ { 1 } , \alpha _ { 2 } , \dots , \alpha _ { p }\). That is familywide error rate \(\leq \Sigma \alpha _ { i }\). In terms of the familywide confidence that all intervals capture their population means, we can write this as \(1  \Sigma \alpha _ { i } \leq\) familywide confidence level.
Most often, we divide the desired familywide error rate equally across the intervals that we will compute. If we are computing p confidence intervals with a desired family wide confidence level of \(\alpha\), we use an error rate of \(\alpha / p\) (so confidence \(= 1  (\alpha / p)\) for each individual interval. This guarantees that the family wide confidence level will be greater than or equal to \(1  \alpha\).
Suppose that we are calculating p intervals with a family error rate equal to \(\alpha\).
Notationally, the Bonferroni method multiplier is:
\(\text{Multiplier} = t_{n1}(\alpha/2p)\)
A confidence interval for\(\mu_{j}\) is computed as:
\(\bar{x}_j \pm t_{n1}(\alpha/2p)\frac{s_j}{\sqrt{n}}\)
Example 52: Bonferroni Method Multiplier
Suppose that n = 25. The family wide error = 5% for a family confidence = 95%. We are computing intervals for p = 5 means. The error rate for each interval will be .05/5 = 1%. We might use the Excel command = TINV(.01,24) to find that the multiplier = 2.797. In SAS, we use the cumulative probability \(= 1 \alpha /2p\) so the command for finding the tmultiplier in this instance is something like t1=tinv(.995, 24).
Simultaneous Confidence Region Multiplier Section
This method is derived from properties of the multivariate normal distribution. The multiplier applies to the family of all possible linear combinations of the population means considered, including the individual means. It is conservative (meaning that the multiplier tends to be larger than absolutely necessary). When family confidence is used, compare the value of this multiplier to the Bonferroni method multiplier and use the smaller of the two.
Notationally, the simultaneous confidence region multiplier is:
\(\text{Multiplier}=\sqrt{\frac{p(n1)}{np}F_{p,np}(\alpha)}\)
\(F _ { p , n  p } ( \alpha )\) represents a value of F such that the probability greater than this value is α under an Fdistribution with p and n  p degrees of freedom.
Example 53: Simultaneous Confidence Region Multiplier
Suppose that we have a sample size of n = 25 and we have p = 3 variables. With a 5% family error rate (and 95% family confidence), the Fvalue can be found in Excel using = FINV(.05, 3, 22) = 3.049. SAS uses cumulative probabilities so in this case, a command like f1= FINV(.95,3, 22) would make f1 be the Fvalue. The multiplier in this example is
\(\sqrt{\frac{3(251)}{253}3.049}=3.159\)
This multiplier could be used for all confidence intervals for parameters that are linear combinations of the three population means (and for the three individual means).
Summary of Multipliers Section
The following table summarizes the three different multipliers and gives notes about using Excel and SAS.
Method  Textbook notation for multiplier  Excel notes  SAS notes 

One at a time: Confidence = (\(1  \alpha)\) for each interval  \(t _ { n  1 } ( \alpha / 2 )\)  To determine the t value, enter the equation TINV(\(\alpha, \text{df}\)) 
To determine the tvalue, create t1= tinv(\(1  \alpha/2,\ n1\)) 
Bonferroni Method: Confidence = \(1  \alpha)\) for whole family 
\(t _ { n  1 } ( \alpha / 2 p )\) 
To determine the t value, enter the equation TINV(α / p, df) 
To determine the t value, create t2= tinv(\(1  \alpha / 2p,\ n1\)) 
Multivariate Simultaneous Intervals 
\(\sqrt{\frac{p(n1)}{np}F_{p,np}(\alpha)}\) 
To determine the F value, enter the equation FINV(\(\alpha,\text{num df, denom df})\) 
To determine the F value, create F= finv(\(1  \alpha, \text{p, np})\) 
Example 54 Section
This example uses the dataset that includes mineral content measurements at three different arm bone locations for n = 25 women . We’ll determine confidence intervals for the three different population means. Sample means and standard deviations for the three variables are:
Variable  N  Mean  Std Dev 

domradius  25  0.84380  0.11402 
domhumerus  25  1.79268  0.28347 
domulna  25  0.70440 
0.10756 
Click to expand the solution using each method.
We’ll use a .95 confidence level for each interval. With n = 25, df = 24 and \(t _ { 24 } ( .025 ) = 2.064\). This can found in Excel as =TINV(.05,24).
The confidence intervals have the form \(\bar{x}_j \pm 2.064\dfrac{s_j}{\sqrt{n}}\). Intervals are the following.
 For dominant radius:
\(0.84380 \pm 2.064 \dfrac{0.11402}{\sqrt{25}}\) which is 0.797 to 0.891
 For dominant humerus:
\(1.79268 \pm 2.064 \dfrac{0.28347}{\sqrt{25}}\) which is 1.676 to 1.910
 For dominant ulna:
\(0.70440 \pm 2.064\dfrac{0.10576}{\sqrt{25}}\) which is 0.660 to 0.749
We’ll use a .95 confidence familywide level so the family error = .05. For each interval, the error rate = .05/3 = 0.16666… The multiplier is \(t _ { 24 } ( .008333 ) = 2.574\) which can be found in Excel as =TINV(.05/3,24).
The confidence intervals have the form \(\bar{x}_j \pm 2.574\dfrac{s_j}{\sqrt{n}}\). Intervals are the following.
 For dominant radius:
\(0.84380 \pm 2.574 \dfrac{0.11402}{\sqrt{25}}\) which is 0.785 to 0.903
 For dominant humerus:
\(1.79268 \pm 2.574 \dfrac{0.28347}{\sqrt{25}}\) which is 1.647 to 1.939
 For dominant ulna:
\(0.70440 \pm 2.574 \dfrac{0.10576}{\sqrt{25}}\) which is 0.649 to 0.760
The necessary F value is \(\sqrt{\dfrac{3(251)}{253}3.049} = 3.159\). (See Example 3 above for details)
The confidence intervals have the form \(\bar{x}_j \pm 3.159 \dfrac{s_j}{\sqrt{n}}\). Intervals are the following.
 For dominant radius:
\(0.84380 \pm 3.159 \dfrac{0.11402}{\sqrt{25}}\) which is 0.772 to 0.916
 For dominant humerus:
\(1.79268 \pm 3.159 \dfrac{0.28347}{\sqrt{25}}\) which is 1.614to 1.972
 For dominant ulna:
\(0.70440 \pm 3.159 \dfrac{0.10576}{\sqrt{25}}\) which is 0.636 to 0.773
Using SAS
Steve Rathbun, formerly of Penn State, wrote the following SAS code (download below) to generate confidence intervals for population means using the three methods discussed here. The code reads a dataset, reshapes it to have a data line for each variable value, determines means and standard deviations and then calculates and prints the three types of intervals. To use this code for different situations, you need only to change the third line where the value of p is set and the data step where the data set is read and reshaped.
Download the SAS program here: CI_pop_means.sas
The output for the program just given is below. It includes the sample mean and variance for each variable and the three confidence intervals. Limits for the one at a time intervals are given as loone and upone. Limits for the Bonferroni method are given as lobon and upbon. Limits for the simultaneous confidence region method are given as losim and upsim.
Variable  N  Mean  Std Dev  Minimum  Maximum 

Calcium  737  624.0492537  397.2775401  7.4400000  2866.44 
Iron  737  11.1298996  5.9841905  0  58.6680000 
Protein  737  65.8034410  30.5757564  0  251.0120000 
A  737  839.3653460  1633.54  0  34434.27 
C  737  78.9284464  73.5952721  0  433.3390000 
Using Minitab
Click on the video below to get walk throughs of the three methods as they are presented below: the oneatatime confidence interval, the Bonferroni method and the multivariate simultaneous interval method, all the Minitab statistical software application.